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Bill Gates surprised even his closest advisers when he said his dream is to eliminate the world's top 20 diseases in his lifetime. Gates-watchers say it's not naïve over-reaching. The Gateses have an optimistic belief in technology and management that, combined with their resources, could make a difference.

In the advertising world of Madison Avenue, three-martini lunches and chain smoking in the office are long gone. But women and minorities are still struggling to make inroads at the top agencies.

The 123-page release mirrors rebuttals that top GOP lawmakers have been making for weeks amid the House Democrats' probe into whether Trump withheld congressionally-appropriated funds for Ukraine.

New York Gov. Kathy Hochul and other top officials weighed the political future of New York City's embattled Mayor Eric Adams. Adams faces growing calls to step down over allegations of corruption

President Trump's top intelligence officials return to Capitol Hill for another hearing where they are likely to face questions about sensitive military information shared with a journalist in a Signal chat.

House Minority Leader Nancy Pelosi agreed to a deal that limits her tenure as the next speaker of the House to four years in return for the votes to officially install her in the top post in January.

The home-improvement retailer Lowe's has reportedly agreed to buy Orchard Supply Hardware Stores. The sale price is expected to top $200 million. Orchard is a California-based hardware-and-garden chain. It was once owned by Sears, and is now about $230 million in debt.

Syrian President Bashar Assad's Instagram account includes images of his smiling first lady. It makes no mention of the country's civil war. Instead, it show his wife helping out in a soup kitchen, and congratulating top achieving students.

A top Japanese diplomat says indirect negotiations to free a captive journalist from the militant Islamic State group have reached a "state of deadlock."

Before the next drawing, on Saturday night, experts say the lottery could top $1 billion.